Endocrine Abstracts

The IGF axis is imperative for normal placental development and function. In the human placenta, IGF1R regulates the actions of IGFs and consequently placental growth. Some microRNAs (miRs) are also known to regulate human placental growth. miR-145 is known to exert its effects on human placental growth by targeting IGF1R. Whilst the expression of some components within the IGF axis are similar between mice and humans, murine expression and function of IGF regulatory miRs has ...

Inadequate wound repair, observed in 15% of diabetics, leads to a chronic wound phenotype and is the leading cause of non-traumatic amputation in the developed world today. Injury induces recruitment of bone marrow-derived cells (BMDCs) to the wound in response to chemoattactant signals, which then contribute to the repair and regeneration process, initially through their role in the inflammatory response. Both granulocytes and monocytes are fundamental at this early stage, bu...

PCOS is a reproductive endocrine disorder that affects up to 10% of women of a reproductive age, with 70-80% of patients defined as infertile. There are many different symptoms that could impact fertility in women with PCOS such as anovulation, hyperandrogenism and insulin resistance. A trophoblast (BeWo cell) spheroid attachment assay was used as an in vitro model of embryo implantation to examine the effect of testosterone on the receptivity of endometrial (Ishikawa...